Drug interactions
Ceftazidime + Voclosporin
Severity: Moderate
Ceftazidime and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin is a calcineurin inhibitor with dose-related nephrotoxicity, and ceftazidime accumulates and can cause harm when renal function is reduced. Using them together may increase the risk of kidney function decline in vulnerable patients.
What this interaction means in plain words
Ceftazidime and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ceftazidime belongs to Anti Bacterial; Voclosporin belongs to Miscellaneous.
Why it happens
Additive nephrotoxic potential, with calcineurin-inhibitor renal vasoconstriction plus possible beta-lactam renal effects.
What to do
Monitor serum creatinine and eGFR during combined therapy and reduce voclosporin per labeling if renal function declines. Adjust ceftazidime dose to creatinine clearance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ceftazidime
- Amikacin + Ceftazidime Moderate
- Ceftazidime + Cholera vaccine Moderate
- Ceftazidime + Dexamethasone-tobramycin Moderate
- Ceftazidime + Gentamicin Moderate
- Ceftazidime + Kanamycin Moderate
- Ceftazidime + Microbiota Moderate
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Ceftazidime with Voclosporin?
MediHelp rates the interaction as moderate. Ceftazidime and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin is a calcineurin inhibitor with dose-related nephrotoxicity, and ceftazidime accumulates and can cause harm when renal function is reduced. Using them together may increase the risk of kidney function decline in vulnerable patients.
How serious is the interaction between Ceftazidime and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and eGFR during combined therapy and reduce voclosporin per labeling if renal function declines. Adjust ceftazidime dose to creatinine clearance.
What other medicines interact with Ceftazidime?
MediHelp also lists interactions of Ceftazidime with, for example, Amikacin, Cholera vaccine, Dexamethasone-tobramycin. The full list is on the Ceftazidime page.
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