Drug interactions
Ceftriaxone + Erythromycin lactobionate
Severity: Minor
Ceftriaxone and Erythromycin lactobionate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macrolides are bacteriostatic and may theoretically reduce the bactericidal effect of beta-lactams. Clinical significance is uncertain, and combinations are often used deliberately, for example in community-acquired pneumonia.
What this interaction means in plain words
Ceftriaxone and Erythromycin lactobionate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ceftriaxone belongs to Anti Bacterial; Erythromycin lactobionate belongs to Anti Bacterial.
Why it happens
Pharmacodynamic antagonism: inhibition of bacterial protein synthesis may reduce growth-dependent killing by ceftriaxone.
What to do
No change is needed when the combination is guideline-supported. Monitor clinical response in severe infection.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ceftriaxone
- Calcium chloride + Ceftriaxone Contraindicated
- Calcium gluconate + Ceftriaxone Contraindicated
- Calcium + Ceftriaxone Contraindicated
- Ceftriaxone + Lactated ringer's Contraindicated
- Ceftriaxone + Ringer's solution Contraindicated
- Calcium acetate + Ceftriaxone Major
Other interactions of Erythromycin lactobionate
- Cisapride + Erythromycin lactobionate Contraindicated
- Dihydroergotamine + Erythromycin lactobionate Contraindicated
- Dronedarone + Erythromycin lactobionate Contraindicated
- Eletriptan + Erythromycin lactobionate Contraindicated
- Ergotamine + Erythromycin lactobionate Contraindicated
- Erythromycin lactobionate + Flibanserin Contraindicated
Frequently asked questions
Can I take Ceftriaxone with Erythromycin lactobionate?
MediHelp rates the interaction as minor. Ceftriaxone and Erythromycin lactobionate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Macrolides are bacteriostatic and may theoretically reduce the bactericidal effect of beta-lactams. Clinical significance is uncertain, and combinations are often used deliberately, for example in community-acquired pneumonia.
How serious is the interaction between Ceftriaxone and Erythromycin lactobionate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No change is needed when the combination is guideline-supported. Monitor clinical response in severe infection.
What other medicines interact with Ceftriaxone?
MediHelp also lists interactions of Ceftriaxone with, for example, Calcium chloride, Calcium gluconate, Calcium. The full list is on the Ceftriaxone page.
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