Drug interactions
Ceftriaxone + Plazomicin
Severity: Minor
Ceftriaxone and Plazomicin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Plazomicin is nephrotoxic and ototoxic, and combining it with other agents that may affect renal function could add to kidney injury risk. Ceftriaxone has little intrinsic nephrotoxicity, so the added risk is small, but renal impairment would raise plazomicin exposure and toxicity.
What this interaction means in plain words
Ceftriaxone and Plazomicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ceftriaxone belongs to Anti Bacterial; Plazomicin belongs to Anti Bacterial.
Why it happens
Possible additive nephrotoxicity, though ceftriaxone itself is rarely nephrotoxic and the aminoglycoside accounts for most of the risk.
What to do
Monitor serum creatinine and plazomicin trough concentrations per labeling. Adjust the plazomicin dose if renal function declines.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ceftriaxone
- Calcium chloride + Ceftriaxone Contraindicated
- Calcium gluconate + Ceftriaxone Contraindicated
- Calcium + Ceftriaxone Contraindicated
- Ceftriaxone + Lactated ringer's Contraindicated
- Ceftriaxone + Ringer's solution Contraindicated
- Calcium acetate + Ceftriaxone Major
Other interactions of Plazomicin
- Cefaclor + Plazomicin Moderate
- Cefadroxil + Plazomicin Moderate
- Cefalexin + Plazomicin Moderate
- Cefazolin + Plazomicin Moderate
- Cefditoren + Plazomicin Moderate
- Cefepime + Plazomicin Moderate
Frequently asked questions
Can I take Ceftriaxone with Plazomicin?
MediHelp rates the interaction as minor. Ceftriaxone and Plazomicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Plazomicin is nephrotoxic and ototoxic, and combining it with other agents that may affect renal function could add to kidney injury risk. Ceftriaxone has little intrinsic nephrotoxicity, so the added risk is small, but renal impairment would raise plazomicin exposure and toxicity.
How serious is the interaction between Ceftriaxone and Plazomicin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and plazomicin trough concentrations per labeling. Adjust the plazomicin dose if renal function declines.
What other medicines interact with Ceftriaxone?
MediHelp also lists interactions of Ceftriaxone with, for example, Calcium chloride, Calcium gluconate, Calcium. The full list is on the Ceftriaxone page.
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