Drug interactions
Cefuroxime + Esomeprazole
Severity: Moderate
Cefuroxime and Esomeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cefuroxime axetil absorption is reduced when gastric acidity is lowered, particularly in the fasted state. This can lower antibiotic exposure and reduce efficacy.
What this interaction means in plain words
Cefuroxime and Esomeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefuroxime belongs to Anti Bacterial; Esomeprazole belongs to Gastrointestinal Tract.
Why it happens
Higher gastric pH reduces the dissolution and absorption of cefuroxime axetil.
What to do
Give cefuroxime axetil with food to improve absorption, and monitor the clinical response. Consider an alternative antibiotic if the infection is serious.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esomeprazole
- Esomeprazole + Mavacamten Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Esomeprazole Major
- Atazanavir + Esomeprazole Major
- Citalopram + Esomeprazole Major
- Clopidogrel + Esomeprazole Major
Other interactions of Cefuroxime
- Aluminum hydroxide + Cefuroxime Moderate
- Amikacin + Cefuroxime Moderate
- Bcg vaccine live + Cefuroxime Moderate
- Calcium carbonate + Cefuroxime Moderate
- Calcium + Cefuroxime Moderate
- Cefuroxime + Cholera vaccine Moderate
Frequently asked questions
Can I take Cefuroxime with Esomeprazole?
MediHelp rates the interaction as moderate. Cefuroxime and Esomeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cefuroxime axetil absorption is reduced when gastric acidity is lowered, particularly in the fasted state. This can lower antibiotic exposure and reduce efficacy.
How serious is the interaction between Cefuroxime and Esomeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give cefuroxime axetil with food to improve absorption, and monitor the clinical response. Consider an alternative antibiotic if the infection is serious.
What other medicines interact with Esomeprazole?
MediHelp also lists interactions of Esomeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Esomeprazole page.
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