Drug interactions
Cefuroxime + Plazomicin
Severity: Moderate
Cefuroxime and Plazomicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Plazomicin is an aminoglycoside with nephrotoxic, ototoxic and neuromuscular-blocking potential. Concurrent cephalosporin use may add to renal stress, and kidney injury raises plazomicin exposure and toxicity.
What this interaction means in plain words
Cefuroxime and Plazomicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefuroxime belongs to Anti Bacterial; Plazomicin belongs to Anti Bacterial.
Why it happens
Additive nephrotoxicity with reduced aminoglycoside clearance when renal function declines.
What to do
Monitor serum creatinine before and during therapy and use therapeutic drug monitoring of plazomicin as labeled. Adjust the dose if renal function changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cefuroxime
- Aluminum hydroxide + Cefuroxime Moderate
- Amikacin + Cefuroxime Moderate
- Bcg vaccine live + Cefuroxime Moderate
- Calcium carbonate + Cefuroxime Moderate
- Calcium + Cefuroxime Moderate
- Cefuroxime + Cholera vaccine Moderate
Other interactions of Plazomicin
- Cefaclor + Plazomicin Moderate
- Cefadroxil + Plazomicin Moderate
- Cefalexin + Plazomicin Moderate
- Cefazolin + Plazomicin Moderate
- Cefditoren + Plazomicin Moderate
- Cefepime + Plazomicin Moderate
Frequently asked questions
Can I take Cefuroxime with Plazomicin?
MediHelp rates the interaction as moderate. Cefuroxime and Plazomicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Plazomicin is an aminoglycoside with nephrotoxic, ototoxic and neuromuscular-blocking potential. Concurrent cephalosporin use may add to renal stress, and kidney injury raises plazomicin exposure and toxicity.
How serious is the interaction between Cefuroxime and Plazomicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine before and during therapy and use therapeutic drug monitoring of plazomicin as labeled. Adjust the dose if renal function changes.
What other medicines interact with Cefuroxime?
MediHelp also lists interactions of Cefuroxime with, for example, Aluminum hydroxide, Amikacin, Bcg vaccine live. The full list is on the Cefuroxime page.
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