Drug interactions
Celecoxib + Clomipramine
Severity: Moderate
Celecoxib and Clomipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine's serotonergic action impairs platelet function, increasing bleeding risk with an NSAID. Celecoxib is a weak CYP2D6 inhibitor and may modestly increase clomipramine exposure.
What this interaction means in plain words
Celecoxib and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Clomipramine belongs to Central Nervous System.
Why it happens
Platelet serotonin reuptake inhibition adds to NSAID effects on hemostasis and mucosa, and weak CYP2D6 inhibition may raise tricyclic levels.
What to do
Monitor for bleeding and for tricyclic adverse effects such as anticholinergic symptoms or arrhythmia, and consider gastroprotection in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Celecoxib with Clomipramine?
MediHelp rates the interaction as moderate. Celecoxib and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine's serotonergic action impairs platelet function, increasing bleeding risk with an NSAID. Celecoxib is a weak CYP2D6 inhibitor and may modestly increase clomipramine exposure.
How serious is the interaction between Celecoxib and Clomipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and for tricyclic adverse effects such as anticholinergic symptoms or arrhythmia, and consider gastroprotection in high-risk patients.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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