Drug interactions
Celecoxib + Dalteparin
Severity: Moderate
Celecoxib and Dalteparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent use raises the risk of bleeding, particularly gastrointestinal hemorrhage, because NSAIDs add antiplatelet and mucosal effects to anticoagulation.
What this interaction means in plain words
Celecoxib and Dalteparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Dalteparin belongs to Cardiovascular.
Why it happens
Additive effects on hemostasis: low-molecular-weight heparin potentiates antithrombin while NSAIDs impair platelet function and injure GI mucosa.
What to do
Avoid unless necessary and monitor for bleeding and hemoglobin. Consider acetaminophen as an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Frequently asked questions
Can I take Celecoxib with Dalteparin?
MediHelp rates the interaction as moderate. Celecoxib and Dalteparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent use raises the risk of bleeding, particularly gastrointestinal hemorrhage, because NSAIDs add antiplatelet and mucosal effects to anticoagulation.
How serious is the interaction between Celecoxib and Dalteparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unless necessary and monitor for bleeding and hemoglobin. Consider acetaminophen as an alternative analgesic.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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