Drug interactions
Celecoxib + Edoxaban
Severity: Major
Celecoxib and Edoxaban: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Taking an NSAID with edoxaban increases the risk of clinically significant bleeding, especially from the gastrointestinal tract. The risk rises with age, renal impairment and long-term NSAID use.
What this interaction means in plain words
Celecoxib and Edoxaban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Celecoxib belongs to Musculoskeletal; Edoxaban belongs to Cardiovascular.
Why it happens
Additive bleeding risk from factor Xa inhibition combined with NSAID antiplatelet effects and gastric mucosal damage.
What to do
Avoid regular NSAID use where possible and choose acetaminophen. If unavoidable, use the lowest dose for the shortest time, consider gastroprotection and monitor for bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Frequently asked questions
Can I take Celecoxib with Edoxaban?
MediHelp rates the interaction as major. Celecoxib and Edoxaban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Taking an NSAID with edoxaban increases the risk of clinically significant bleeding, especially from the gastrointestinal tract. The risk rises with age, renal impairment and long-term NSAID use.
How serious is the interaction between Celecoxib and Edoxaban?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use where possible and choose acetaminophen. If unavoidable, use the lowest dose for the shortest time, consider gastroprotection and monitor for bleeding.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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