Drug interactions
Celecoxib + Esmolol
Severity: Minor
Celecoxib and Esmolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prolonged NSAID use can reduce the blood pressure lowering effect of beta-blockers through sodium and water retention and prostaglandin inhibition. Esmolol is given short-term, so the practical impact is generally small.
What this interaction means in plain words
Celecoxib and Esmolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Celecoxib belongs to Musculoskeletal; Esmolol belongs to Cardiovascular.
Why it happens
NSAID inhibition of vasodilatory prostaglandins opposes the hemodynamic effect of beta-blockade.
What to do
Monitor blood pressure and heart rate response if esmolol is used in a patient on regular celecoxib.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Frequently asked questions
Can I take Celecoxib with Esmolol?
MediHelp rates the interaction as minor. Celecoxib and Esmolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Prolonged NSAID use can reduce the blood pressure lowering effect of beta-blockers through sodium and water retention and prostaglandin inhibition. Esmolol is given short-term, so the practical impact is generally small.
How serious is the interaction between Celecoxib and Esmolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate response if esmolol is used in a patient on regular celecoxib.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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