Drug interactions
Celecoxib + Ethacrynic acid
Severity: Moderate
Celecoxib and Ethacrynic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce the diuretic and antihypertensive effect of loop diuretics through sodium retention and reduced renal prostaglandins. Combined use also raises the risk of acute kidney injury in volume-depleted patients.
What this interaction means in plain words
Celecoxib and Ethacrynic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Ethacrynic acid belongs to Cardiovascular.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces renal blood flow and natriuretic response to loop diuretics.
What to do
Monitor diuretic response, weight, blood pressure, renal function and electrolytes. Increase the diuretic dose if needed or avoid the NSAID in heart failure or renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Celecoxib with Ethacrynic acid?
MediHelp rates the interaction as moderate. Celecoxib and Ethacrynic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce the diuretic and antihypertensive effect of loop diuretics through sodium retention and reduced renal prostaglandins. Combined use also raises the risk of acute kidney injury in volume-depleted patients.
How serious is the interaction between Celecoxib and Ethacrynic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor diuretic response, weight, blood pressure, renal function and electrolytes. Increase the diuretic dose if needed or avoid the NSAID in heart failure or renal impairment.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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