Drug interactions
Celecoxib + Ethinyl estradiol-drospirenone
Severity: Minor
Celecoxib and Ethinyl estradiol-drospirenone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce renal prostaglandin synthesis, lowering renin and aldosterone and impairing potassium excretion. Combined with drospirenone, this may add to the potassium-raising effect, although drospirenone labeling does not require monitoring for occasional NSAID use in healthy women.
What this interaction means in plain words
Celecoxib and Ethinyl estradiol-drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Celecoxib belongs to Musculoskeletal; Ethinyl estradiol-drospirenone belongs to Endocrine.
Why it happens
Additive potassium retention from aldosterone antagonism (drospirenone) and NSAID-induced suppression of the renin-aldosterone axis and renal prostaglandins.
What to do
For long-term daily NSAID use, check serum potassium during the first cycle. Use the lowest effective NSAID dose, and take extra care in patients with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Celecoxib with Ethinyl estradiol-drospirenone?
MediHelp rates the interaction as minor. Celecoxib and Ethinyl estradiol-drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs can reduce renal prostaglandin synthesis, lowering renin and aldosterone and impairing potassium excretion. Combined with drospirenone, this may add to the potassium-raising effect, although drospirenone labeling does not require monitoring for occasional NSAID use in healthy women.
How serious is the interaction between Celecoxib and Ethinyl estradiol-drospirenone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: For long-term daily NSAID use, check serum potassium during the first cycle. Use the lowest effective NSAID dose, and take extra care in patients with renal impairment.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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