Drug interactions
Celecoxib + Fluphenazine
Severity: Minor
Celecoxib and Fluphenazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Celecoxib may modestly increase fluphenazine levels via weak CYP2D6 inhibition. Clinical effect is likely small but could add to extrapyramidal symptoms or sedation.
What this interaction means in plain words
Celecoxib and Fluphenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Celecoxib belongs to Musculoskeletal; Fluphenazine belongs to Central Nervous System.
Why it happens
Celecoxib weakly inhibits CYP2D6, which metabolizes fluphenazine.
What to do
No routine adjustment; monitor for extrapyramidal symptoms and sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Celecoxib with Fluphenazine?
MediHelp rates the interaction as minor. Celecoxib and Fluphenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Celecoxib may modestly increase fluphenazine levels via weak CYP2D6 inhibition. Clinical effect is likely small but could add to extrapyramidal symptoms or sedation.
How serious is the interaction between Celecoxib and Fluphenazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment; monitor for extrapyramidal symptoms and sedation.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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