Drug interactions
Celecoxib + Fluvoxamine
Severity: Moderate
Celecoxib and Fluvoxamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine inhibits CYP2C9 and can raise celecoxib concentrations, increasing the risk of dose-related adverse effects such as GI, renal and cardiovascular events. SSRIs also add to NSAID-associated bleeding risk.
What this interaction means in plain words
Celecoxib and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Fluvoxamine belongs to Central Nervous System.
Why it happens
Fluvoxamine inhibition of CYP2C9 reduces celecoxib clearance; SSRI platelet effects add to bleeding risk.
What to do
Start celecoxib at the lowest dose and monitor for adverse effects and bleeding. Consider gastroprotection in at-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Celecoxib with Fluvoxamine?
MediHelp rates the interaction as moderate. Celecoxib and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluvoxamine inhibits CYP2C9 and can raise celecoxib concentrations, increasing the risk of dose-related adverse effects such as GI, renal and cardiovascular events. SSRIs also add to NSAID-associated bleeding risk.
How serious is the interaction between Celecoxib and Fluvoxamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start celecoxib at the lowest dose and monitor for adverse effects and bleeding. Consider gastroprotection in at-risk patients.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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