Drug interactions
Celecoxib + Gemifloxacin
Severity: Moderate
Celecoxib and Gemifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may increase the risk of CNS stimulation and seizures with fluoroquinolones. The risk is small but relevant in predisposed patients.
What this interaction means in plain words
Celecoxib and Gemifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Gemifloxacin belongs to Anti Bacterial.
Why it happens
Fluoroquinolone GABA-A receptor antagonism may be potentiated by NSAIDs; mechanism not firmly established.
What to do
Avoid in patients with seizure history or other predisposing factors. Counsel patients to report tremor, agitation or seizures.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Frequently asked questions
Can I take Celecoxib with Gemifloxacin?
MediHelp rates the interaction as moderate. Celecoxib and Gemifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may increase the risk of CNS stimulation and seizures with fluoroquinolones. The risk is small but relevant in predisposed patients.
How serious is the interaction between Celecoxib and Gemifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in patients with seizure history or other predisposing factors. Counsel patients to report tremor, agitation or seizures.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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