Drug interactions
Celecoxib + Gentamicin
Severity: Moderate
Celecoxib and Gentamicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce renal function and decrease aminoglycoside clearance, which may raise gentamicin levels and increase the risk of nephrotoxicity and ototoxicity. The risk is higher in neonates, the elderly, and dehydrated patients.
What this interaction means in plain words
Celecoxib and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Gentamicin belongs to Anti Bacterial.
Why it happens
NSAID-induced reduction in renal prostaglandins and glomerular filtration lowers aminoglycoside excretion and adds to nephrotoxicity.
What to do
Monitor serum creatinine and gentamicin trough levels, and avoid combining where possible in patients with renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Frequently asked questions
Can I take Celecoxib with Gentamicin?
MediHelp rates the interaction as moderate. Celecoxib and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce renal function and decrease aminoglycoside clearance, which may raise gentamicin levels and increase the risk of nephrotoxicity and ototoxicity. The risk is higher in neonates, the elderly, and dehydrated patients.
How serious is the interaction between Celecoxib and Gentamicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and gentamicin trough levels, and avoid combining where possible in patients with renal impairment.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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