Drug interactions
Celecoxib + Haloperidol
Severity: Moderate
Celecoxib and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol is partly metabolized by CYP2D6, and celecoxib is a moderate CYP2D6 inhibitor, so haloperidol levels may increase. Higher exposure could worsen extrapyramidal symptoms, sedation, and QT prolongation.
What this interaction means in plain words
Celecoxib and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Haloperidol belongs to Central Nervous System.
Why it happens
Celecoxib inhibits CYP2D6, reducing haloperidol clearance.
What to do
Monitor for extrapyramidal symptoms and sedation, and check ECG if other QT-prolonging factors are present. Reduce the haloperidol dose if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Celecoxib with Haloperidol?
MediHelp rates the interaction as moderate. Celecoxib and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Haloperidol is partly metabolized by CYP2D6, and celecoxib is a moderate CYP2D6 inhibitor, so haloperidol levels may increase. Higher exposure could worsen extrapyramidal symptoms, sedation, and QT prolongation.
How serious is the interaction between Celecoxib and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms and sedation, and check ECG if other QT-prolonging factors are present. Reduce the haloperidol dose if adverse effects emerge.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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