Drug interactions
Celecoxib + Iloperidone
Severity: Moderate
Celecoxib and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is metabolized by CYP2D6 and CYP3A4, and celecoxib's CYP2D6 inhibition may raise iloperidone levels. This could increase QT prolongation, orthostatic hypotension and sedation.
What this interaction means in plain words
Celecoxib and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Iloperidone belongs to Central Nervous System.
Why it happens
Celecoxib inhibits CYP2D6, reducing iloperidone clearance.
What to do
Monitor for QT-related symptoms, hypotension and sedation, and consider ECG monitoring in patients with cardiac risk factors. Use the lowest effective iloperidone dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Celecoxib and Iloperidone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Celecoxib with Iloperidone?
MediHelp rates the interaction as moderate. Celecoxib and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone is metabolized by CYP2D6 and CYP3A4, and celecoxib's CYP2D6 inhibition may raise iloperidone levels. This could increase QT prolongation, orthostatic hypotension and sedation.
How serious is the interaction between Celecoxib and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for QT-related symptoms, hypotension and sedation, and consider ECG monitoring in patients with cardiac risk factors. Use the lowest effective iloperidone dose.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
