Drug interactions
Celecoxib + Imidapril
Severity: Moderate
Celecoxib and Imidapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce the antihypertensive effect of ACE inhibitors and may increase the risk of acute kidney injury, particularly in older, volume-depleted or renally impaired patients. Hyperkalemia may also occur.
What this interaction means in plain words
Celecoxib and Imidapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Imidapril belongs to Cardiovascular.
Why it happens
Inhibition of vasodilatory renal prostaglandins counteracts ACE inhibitor effects and reduces glomerular perfusion.
What to do
Monitor blood pressure, serum creatinine and potassium, ensure adequate hydration, and use the lowest effective celecoxib dose for the shortest duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Imidapril
- Amiloride + Imidapril Major
- Eplerenone + Imidapril Major
- Imidapril + Lithium Major
- Imidapril + Pregabalin Major
- Imidapril + Spironolactone Major
- Imidapril + Triamterene Major
Frequently asked questions
Can I take Celecoxib with Imidapril?
MediHelp rates the interaction as moderate. Celecoxib and Imidapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce the antihypertensive effect of ACE inhibitors and may increase the risk of acute kidney injury, particularly in older, volume-depleted or renally impaired patients. Hyperkalemia may also occur.
How serious is the interaction between Celecoxib and Imidapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium, ensure adequate hydration, and use the lowest effective celecoxib dose for the shortest duration.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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