Drug interactions
Celecoxib + Metoprolol
Severity: Moderate
Celecoxib and Metoprolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Celecoxib inhibits CYP2D6 and can raise metoprolol exposure, with possible bradycardia or hypotension. NSAIDs may also blunt the antihypertensive effect of beta-blockers.
What this interaction means in plain words
Celecoxib and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Metoprolol belongs to Cardiovascular.
Why it happens
CYP2D6 inhibition by celecoxib reduces metoprolol clearance, while NSAID prostaglandin inhibition causes fluid retention opposing blood pressure lowering.
What to do
Monitor heart rate and blood pressure when starting or stopping celecoxib. Adjust the metoprolol dose according to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Frequently asked questions
Can I take Celecoxib with Metoprolol?
MediHelp rates the interaction as moderate. Celecoxib and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Celecoxib inhibits CYP2D6 and can raise metoprolol exposure, with possible bradycardia or hypotension. NSAIDs may also blunt the antihypertensive effect of beta-blockers.
How serious is the interaction between Celecoxib and Metoprolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when starting or stopping celecoxib. Adjust the metoprolol dose according to response.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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