Drug interactions
Celecoxib + Peginterferon alfa 2b
Severity: Minor
Celecoxib and Peginterferon alfa 2b: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Peginterferon alfa-2b may modestly alter CYP-mediated clearance of some drugs, and celecoxib is a CYP2C9 substrate. Evidence of a clinically relevant change in celecoxib exposure is lacking.
What this interaction means in plain words
Celecoxib and Peginterferon alfa 2b have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Celecoxib belongs to Musculoskeletal; Peginterferon alfa 2b belongs to Anti Virals.
Why it happens
Interferon-related modulation of hepatic CYP activity may change celecoxib metabolism, but the effect is not well established.
What to do
No empirical dose change is needed; monitor analgesic response and adverse effects of celecoxib.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Peginterferon alfa 2b
Frequently asked questions
Can I take Celecoxib with Peginterferon alfa 2b?
MediHelp rates the interaction as minor. Celecoxib and Peginterferon alfa 2b have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Peginterferon alfa-2b may modestly alter CYP-mediated clearance of some drugs, and celecoxib is a CYP2C9 substrate. Evidence of a clinically relevant change in celecoxib exposure is lacking.
How serious is the interaction between Celecoxib and Peginterferon alfa 2b?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed; monitor analgesic response and adverse effects of celecoxib.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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