Drug interactions
Celecoxib + Promethazine
Severity: Minor
Celecoxib and Promethazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Celecoxib is a weak CYP2D6 inhibitor and could modestly raise promethazine exposure. A clinically important effect is not well documented and would most likely appear as extra drowsiness.
What this interaction means in plain words
Celecoxib and Promethazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Celecoxib belongs to Musculoskeletal; Promethazine belongs to Respiratory.
Why it happens
Celecoxib weakly inhibits CYP2D6-mediated promethazine metabolism.
What to do
No routine adjustment is needed. Watch for increased sedation and reduce the promethazine dose if it occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Promethazine
- Cabergoline + Promethazine Contraindicated
- Dopamine + Promethazine Contraindicated
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Celecoxib with Promethazine?
MediHelp rates the interaction as minor. Celecoxib and Promethazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Celecoxib is a weak CYP2D6 inhibitor and could modestly raise promethazine exposure. A clinically important effect is not well documented and would most likely appear as extra drowsiness.
How serious is the interaction between Celecoxib and Promethazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Watch for increased sedation and reduce the promethazine dose if it occurs.
What other medicines interact with Promethazine?
MediHelp also lists interactions of Promethazine with, for example, Cabergoline, Dopamine, Ibutilide. The full list is on the Promethazine page.
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