Drug interactions
Celecoxib + Torsemide
Severity: Moderate
Celecoxib and Torsemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce the diuretic and antihypertensive effect of loop diuretics through sodium retention. In susceptible patients such as the elderly or those with heart failure, the combination may also contribute to renal impairment.
What this interaction means in plain words
Celecoxib and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Torsemide belongs to Cardiovascular.
Why it happens
NSAID inhibition of renal prostaglandins reduces diuretic-induced renal blood flow and natriuresis.
What to do
Monitor weight, edema, blood pressure and renal function, and increase diuretic dose if response declines. Prefer the lowest effective NSAID dose or an alternative analgesic in heart failure or renal disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Torsemide
Frequently asked questions
Can I take Celecoxib with Torsemide?
MediHelp rates the interaction as moderate. Celecoxib and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce the diuretic and antihypertensive effect of loop diuretics through sodium retention. In susceptible patients such as the elderly or those with heart failure, the combination may also contribute to renal impairment.
How serious is the interaction between Celecoxib and Torsemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor weight, edema, blood pressure and renal function, and increase diuretic dose if response declines. Prefer the lowest effective NSAID dose or an alternative analgesic in heart failure or renal disease.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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