Drug interactions
Celecoxib + Voriconazole
Severity: Moderate
Celecoxib and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole inhibits CYP2C9 and CYP2C19 and can raise celecoxib exposure. Higher celecoxib levels may increase dose-related adverse effects such as gastrointestinal, renal and cardiovascular toxicity. The effect is clearer in patients who are CYP2C9 poor metabolizers.
What this interaction means in plain words
Celecoxib and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP2C9-mediated metabolism of celecoxib, increasing its plasma concentration.
What to do
Consider starting celecoxib at the lowest dose and reducing it if needed; monitor for GI bleeding, fluid retention and blood pressure changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Celecoxib with Voriconazole?
MediHelp rates the interaction as moderate. Celecoxib and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole inhibits CYP2C9 and CYP2C19 and can raise celecoxib exposure. Higher celecoxib levels may increase dose-related adverse effects such as gastrointestinal, renal and cardiovascular toxicity. The effect is clearer in patients who are CYP2C9 poor metabolizers.
How serious is the interaction between Celecoxib and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider starting celecoxib at the lowest dose and reducing it if needed; monitor for GI bleeding, fluid retention and blood pressure changes.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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