Drug interactions
Cenobamate + Chlorpromazine
Severity: Moderate
Cenobamate and Chlorpromazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate commonly causes somnolence, dizziness, and cognitive effects, and chlorpromazine adds sedation. Both drugs may also lower the seizure threshold or alter each other's levels, so the combination calls for attention.
What this interaction means in plain words
Cenobamate and Chlorpromazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Chlorpromazine belongs to Central Nervous System.
Why it happens
Additive CNS depression; cenobamate also modulates CYP enzymes, but the effect on chlorpromazine has not been well characterized.
What to do
Monitor sedation, coordination, and seizure control. Counsel patients about driving, and reduce doses if impairment occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Chlorpromazine?
MediHelp rates the interaction as moderate. Cenobamate and Chlorpromazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate commonly causes somnolence, dizziness, and cognitive effects, and chlorpromazine adds sedation. Both drugs may also lower the seizure threshold or alter each other's levels, so the combination calls for attention.
How serious is the interaction between Cenobamate and Chlorpromazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, coordination, and seizure control. Counsel patients about driving, and reduce doses if impairment occurs.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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