Drug interactions
Cenobamate + Enzalutamide
Severity: Moderate
Cenobamate and Enzalutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate is a CYP3A4 inducer and may lower enzalutamide exposure. Enzalutamide's active metabolite is also partly cleared by CYP3A4, though the total active moiety is likely affected only modestly. Cenobamate may also be affected by enzalutamide induction.
What this interaction means in plain words
Cenobamate and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Enzalutamide belongs to Endocrine.
Why it happens
Cenobamate induces CYP3A4, increasing metabolism of enzalutamide, while enzalutamide may induce cenobamate clearance.
What to do
Monitor PSA and radiographic response for enzalutamide, and seizure control for cenobamate. Adjust doses based on clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Enzalutamide?
MediHelp rates the interaction as moderate. Cenobamate and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate is a CYP3A4 inducer and may lower enzalutamide exposure. Enzalutamide's active metabolite is also partly cleared by CYP3A4, though the total active moiety is likely affected only modestly. Cenobamate may also be affected by enzalutamide induction.
How serious is the interaction between Cenobamate and Enzalutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor PSA and radiographic response for enzalutamide, and seizure control for cenobamate. Adjust doses based on clinical response.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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