Drug interactions
Cenobamate + Medroxyprogesterone
Severity: Moderate
Cenobamate and Medroxyprogesterone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate induces CYP3A4 and may lower medroxyprogesterone exposure. This could reduce efficacy in contraception or endometrial protection.
What this interaction means in plain words
Cenobamate and Medroxyprogesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Medroxyprogesterone belongs to Endocrine.
Why it happens
Cenobamate induces CYP3A4, increasing medroxyprogesterone metabolism.
What to do
Monitor for loss of effect and consider additional non-hormonal contraception. Adjust the dose if clinically needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Medroxyprogesterone
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Medroxyprogesterone?
MediHelp rates the interaction as moderate. Cenobamate and Medroxyprogesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate induces CYP3A4 and may lower medroxyprogesterone exposure. This could reduce efficacy in contraception or endometrial protection.
How serious is the interaction between Cenobamate and Medroxyprogesterone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of effect and consider additional non-hormonal contraception. Adjust the dose if clinically needed.
What other medicines interact with Medroxyprogesterone?
MediHelp also lists interactions of Medroxyprogesterone with, for example, Bosentan, Brigatinib, Eslicarbazepine. The full list is on the Medroxyprogesterone page.
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