Drug interactions
Eslicarbazepine + Medroxyprogesterone
Severity: Major
Eslicarbazepine and Medroxyprogesterone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eslicarbazepine may lower progestin levels, risking contraceptive failure or reduced effect in hormone therapy.
What this interaction means in plain words
Eslicarbazepine and Medroxyprogesterone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eslicarbazepine belongs to Central Nervous System; Medroxyprogesterone belongs to Endocrine.
Why it happens
CYP3A4 induction increases progestin metabolism.
What to do
Use an additional or alternative contraceptive such as a copper or levonorgestrel IUD; shorten injection intervals only with prescriber guidance.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Other interactions of Medroxyprogesterone
Frequently asked questions
Can I take Eslicarbazepine with Medroxyprogesterone?
MediHelp rates the interaction as major. Eslicarbazepine and Medroxyprogesterone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eslicarbazepine may lower progestin levels, risking contraceptive failure or reduced effect in hormone therapy.
How serious is the interaction between Eslicarbazepine and Medroxyprogesterone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an additional or alternative contraceptive such as a copper or levonorgestrel IUD; shorten injection intervals only with prescriber guidance.
What other medicines interact with Eslicarbazepine?
MediHelp also lists interactions of Eslicarbazepine with, for example, Mavacamten, Rilpivirine, Artemether / lumefantrine. The full list is on the Eslicarbazepine page.
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