Drug interactions
Bosentan + Medroxyprogesterone
Severity: Major
Bosentan and Medroxyprogesterone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan induces CYP3A4 and may lower medroxyprogesterone exposure. For contraceptive use this can reduce efficacy and raise the chance of unintended pregnancy, which is especially concerning because bosentan is teratogenic.
What this interaction means in plain words
Bosentan and Medroxyprogesterone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bosentan belongs to Miscellaneous; Medroxyprogesterone belongs to Endocrine.
Why it happens
Bosentan induces CYP3A4, increasing the metabolism of medroxyprogesterone.
What to do
Do not rely on hormonal contraception alone in patients taking bosentan; add or switch to a reliable non-interacting method such as an intrauterine device. Monitor for breakthrough bleeding and perform pregnancy tests as indicated.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Medroxyprogesterone
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Cyclosporine Contraindicated
- Bosentan + Glyburide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
Frequently asked questions
Can I take Bosentan with Medroxyprogesterone?
MediHelp rates the interaction as major. Bosentan and Medroxyprogesterone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bosentan induces CYP3A4 and may lower medroxyprogesterone exposure. For contraceptive use this can reduce efficacy and raise the chance of unintended pregnancy, which is especially concerning because bosentan is teratogenic.
How serious is the interaction between Bosentan and Medroxyprogesterone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not rely on hormonal contraception alone in patients taking bosentan; add or switch to a reliable non-interacting method such as an intrauterine device. Monitor for breakthrough bleeding and perform pregnancy tests as indicated.
What other medicines interact with Medroxyprogesterone?
MediHelp also lists interactions of Medroxyprogesterone with, for example, Brigatinib, Eslicarbazepine, Fosphenytoin. The full list is on the Medroxyprogesterone page.
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