Drug interactions
Brigatinib + Medroxyprogesterone
Severity: Major
Brigatinib and Medroxyprogesterone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brigatinib may induce CYP3A4 and could lower medroxyprogesterone exposure, risking contraceptive failure. Brigatinib is also fetotoxic, so reliable contraception is essential.
What this interaction means in plain words
Brigatinib and Medroxyprogesterone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Brigatinib belongs to Oncology; Medroxyprogesterone belongs to Endocrine.
Why it happens
Brigatinib induces CYP3A4, which may increase medroxyprogesterone metabolism.
What to do
Use an effective non-hormonal contraceptive method during brigatinib treatment and for at least 4 months after the last dose. Do not rely on hormonal contraception alone.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Brigatinib and Medroxyprogesterone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Medroxyprogesterone
Other interactions of Brigatinib
Frequently asked questions
Can I take Brigatinib with Medroxyprogesterone?
MediHelp rates the interaction as major. Brigatinib and Medroxyprogesterone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Brigatinib may induce CYP3A4 and could lower medroxyprogesterone exposure, risking contraceptive failure. Brigatinib is also fetotoxic, so reliable contraception is essential.
How serious is the interaction between Brigatinib and Medroxyprogesterone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an effective non-hormonal contraceptive method during brigatinib treatment and for at least 4 months after the last dose. Do not rely on hormonal contraception alone.
What other medicines interact with Medroxyprogesterone?
MediHelp also lists interactions of Medroxyprogesterone with, for example, Bosentan, Eslicarbazepine, Fosphenytoin. The full list is on the Medroxyprogesterone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
