Drug interactions
Ivosidenib + Medroxyprogesterone
Severity: Major
Ivosidenib and Medroxyprogesterone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces CYP3A4 and may reduce medroxyprogesterone exposure. This could cause loss of contraceptive or therapeutic efficacy.
What this interaction means in plain words
Ivosidenib and Medroxyprogesterone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ivosidenib belongs to Oncology; Medroxyprogesterone belongs to Endocrine.
Why it happens
Ivosidenib induces CYP3A4, increasing medroxyprogesterone metabolism.
What to do
Use a non-hormonal contraceptive method or add a barrier method during therapy. Monitor for loss of efficacy when medroxyprogesterone is used therapeutically.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ivosidenib and Medroxyprogesterone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Medroxyprogesterone
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Ivosidenib with Medroxyprogesterone?
MediHelp rates the interaction as major. Ivosidenib and Medroxyprogesterone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ivosidenib induces CYP3A4 and may reduce medroxyprogesterone exposure. This could cause loss of contraceptive or therapeutic efficacy.
How serious is the interaction between Ivosidenib and Medroxyprogesterone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-hormonal contraceptive method or add a barrier method during therapy. Monitor for loss of efficacy when medroxyprogesterone is used therapeutically.
What other medicines interact with Medroxyprogesterone?
MediHelp also lists interactions of Medroxyprogesterone with, for example, Bosentan, Brigatinib, Eslicarbazepine. The full list is on the Medroxyprogesterone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
