Drug interactions
Cenobamate + Montelukast
Severity: Minor
Cenobamate and Montelukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate is a CYP3A4 inducer and may lower montelukast concentrations, though montelukast is cleared by several enzymes. Reduced asthma or allergy control is possible.
What this interaction means in plain words
Cenobamate and Montelukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cenobamate belongs to Central Nervous System; Montelukast belongs to Respiratory.
Why it happens
Cenobamate induces CYP3A4 (and possibly CYP2C enzymes), increasing montelukast clearance.
What to do
Monitor asthma or allergic rhinitis control after cenobamate is started. Consider adjusting therapy if symptoms worsen.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Montelukast
- Apalutamide + Montelukast Moderate
- Carbamazepine + Montelukast Moderate
- Deferasirox + Montelukast Moderate
- Enzalutamide + Montelukast Moderate
- Fosphenytoin + Montelukast Moderate
- Gemfibrozil + Montelukast Moderate
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Montelukast?
MediHelp rates the interaction as minor. Cenobamate and Montelukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cenobamate is a CYP3A4 inducer and may lower montelukast concentrations, though montelukast is cleared by several enzymes. Reduced asthma or allergy control is possible.
How serious is the interaction between Cenobamate and Montelukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor asthma or allergic rhinitis control after cenobamate is started. Consider adjusting therapy if symptoms worsen.
What other medicines interact with Montelukast?
MediHelp also lists interactions of Montelukast with, for example, Apalutamide, Carbamazepine, Deferasirox. The full list is on the Montelukast page.
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