Drug interactions
Cenobamate + Progesterone
Severity: Moderate
Cenobamate and Progesterone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate induces CYP3A4 and can lower exposure to progesterone. This may reduce efficacy of progesterone used for contraception, endometrial protection or luteal support.
What this interaction means in plain words
Cenobamate and Progesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Progesterone belongs to Endocrine.
Why it happens
Cenobamate induces CYP3A4, increasing hepatic and intestinal metabolism of progesterone.
What to do
Monitor for loss of progestogenic effect and consider a higher progesterone dose if clinically needed. Use an additional or alternative non-hormonal contraceptive method when contraception is the goal.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Progesterone
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Progesterone?
MediHelp rates the interaction as moderate. Cenobamate and Progesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate induces CYP3A4 and can lower exposure to progesterone. This may reduce efficacy of progesterone used for contraception, endometrial protection or luteal support.
How serious is the interaction between Cenobamate and Progesterone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of progestogenic effect and consider a higher progesterone dose if clinically needed. Use an additional or alternative non-hormonal contraceptive method when contraception is the goal.
What other medicines interact with Progesterone?
MediHelp also lists interactions of Progesterone with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Progesterone page.
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