Drug interactions
Cenobamate + Propofol
Severity: Moderate
Cenobamate and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate may induce CYP2B6, which contributes to propofol metabolism, potentially lowering propofol exposure. Cenobamate is also sedating and can add to propofol's CNS depression, so the net effect on dosing is unpredictable.
What this interaction means in plain words
Cenobamate and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Propofol belongs to Central Nervous System.
Why it happens
CYP2B6 induction by cenobamate may speed propofol clearance, while both agents have additive CNS depressant effects.
What to do
Titrate propofol to clinical effect and depth-of-anesthesia monitoring rather than using fixed doses. Monitor for both inadequate anesthesia and excess sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propofol
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Propofol?
MediHelp rates the interaction as moderate. Cenobamate and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate may induce CYP2B6, which contributes to propofol metabolism, potentially lowering propofol exposure. Cenobamate is also sedating and can add to propofol's CNS depression, so the net effect on dosing is unpredictable.
How serious is the interaction between Cenobamate and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol to clinical effect and depth-of-anesthesia monitoring rather than using fixed doses. Monitor for both inadequate anesthesia and excess sedation.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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