Drug interactions
Cenobamate + Ticlopidine
Severity: Minor
Cenobamate and Ticlopidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate induces CYP3A4 and may lower concentrations of CYP3A4 substrates. Ticlopidine is mainly cleared by several pathways and is not a sensitive CYP3A4 substrate, so the clinical effect is uncertain.
What this interaction means in plain words
Cenobamate and Ticlopidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cenobamate belongs to Central Nervous System; Ticlopidine belongs to Cardiovascular.
Why it happens
Possible CYP3A4 induction by cenobamate lowering ticlopidine exposure; clinical relevance is not established.
What to do
No routine adjustment; monitor platelet response and clinical outcomes if the combination is used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ticlopidine
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Ticlopidine?
MediHelp rates the interaction as minor. Cenobamate and Ticlopidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cenobamate induces CYP3A4 and may lower concentrations of CYP3A4 substrates. Ticlopidine is mainly cleared by several pathways and is not a sensitive CYP3A4 substrate, so the clinical effect is uncertain.
How serious is the interaction between Cenobamate and Ticlopidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment; monitor platelet response and clinical outcomes if the combination is used.
What other medicines interact with Ticlopidine?
MediHelp also lists interactions of Ticlopidine with, for example, Mavacamten, Abrocitinib, Acetylsalicylic acid. The full list is on the Ticlopidine page.
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