Drug interactions
Cenobamate + Vilazodone
Severity: Moderate
Cenobamate and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause somnolence, dizziness and impaired concentration. Taken together, these CNS effects may be additive and affect driving or other tasks needing alertness. Cenobamate may also modestly induce CYP3A4, which could lower vilazodone exposure.
What this interaction means in plain words
Cenobamate and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Vilazodone belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects; cenobamate is also a weak-to-moderate CYP3A4 inducer.
What to do
Monitor for excessive sedation and counsel patients about driving. Reassess antidepressant response and adjust vilazodone if efficacy is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Vilazodone?
MediHelp rates the interaction as moderate. Cenobamate and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause somnolence, dizziness and impaired concentration. Taken together, these CNS effects may be additive and affect driving or other tasks needing alertness. Cenobamate may also modestly induce CYP3A4, which could lower vilazodone exposure.
How serious is the interaction between Cenobamate and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and counsel patients about driving. Reassess antidepressant response and adjust vilazodone if efficacy is lost.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
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