Drug interactions
Ceritinib + Desogestrel-ethinyl estradiol
Severity: Moderate
Ceritinib and Desogestrel-ethinyl estradiol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib inhibits CYP3A4 and may increase exposure to ethinyl estradiol, with possible estrogenic adverse effects. However, ceritinib treatment carries embryo-fetal risk and hormonal contraceptives may not be sufficient alone.
What this interaction means in plain words
Ceritinib and Desogestrel-ethinyl estradiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ceritinib belongs to Oncology; Desogestrel-ethinyl estradiol belongs to Endocrine.
Why it happens
Inhibition of CYP3A4 by ceritinib reduces metabolism of ethinyl estradiol.
What to do
Monitor for estrogenic adverse effects and use an additional barrier contraceptive method during therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Aminocaproic acid + Desogestrel-ethinyl estradiol Major
- Amobarbital + Desogestrel-ethinyl estradiol Major
- Anastrozole + Desogestrel-ethinyl estradiol Major
- Apalutamide + Desogestrel-ethinyl estradiol Major
- Atazanavir + Desogestrel-ethinyl estradiol Major
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Desogestrel-ethinyl estradiol?
MediHelp rates the interaction as moderate. Ceritinib and Desogestrel-ethinyl estradiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceritinib inhibits CYP3A4 and may increase exposure to ethinyl estradiol, with possible estrogenic adverse effects. However, ceritinib treatment carries embryo-fetal risk and hormonal contraceptives may not be sufficient alone.
How serious is the interaction between Ceritinib and Desogestrel-ethinyl estradiol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for estrogenic adverse effects and use an additional barrier contraceptive method during therapy.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
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