Drug interactions
Ceritinib + Dexamethasone
Severity: Moderate
Ceritinib and Dexamethasone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone may lower ceritinib concentrations by inducing CYP3A4. Reduced exposure may lessen efficacy in ALK-positive lung cancer.
What this interaction means in plain words
Ceritinib and Dexamethasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ceritinib belongs to Oncology; Dexamethasone belongs to Endocrine.
Why it happens
Dexamethasone induces CYP3A4, increasing metabolism of ceritinib.
What to do
Use the lowest effective dexamethasone dose and duration and monitor for loss of disease control. Avoid strong CYP3A inducers with ceritinib.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Dexamethasone?
MediHelp rates the interaction as moderate. Ceritinib and Dexamethasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexamethasone may lower ceritinib concentrations by inducing CYP3A4. Reduced exposure may lessen efficacy in ALK-positive lung cancer.
How serious is the interaction between Ceritinib and Dexamethasone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective dexamethasone dose and duration and monitor for loss of disease control. Avoid strong CYP3A inducers with ceritinib.
What other medicines interact with Dexamethasone?
MediHelp also lists interactions of Dexamethasone with, for example, Bcg vaccine live, Mifepristone, Rilpivirine. The full list is on the Dexamethasone page.
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