Drug interactions
Ceritinib + Dipyridamole
Severity: Moderate
Ceritinib and Dipyridamole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dipyridamole may inhibit P-glycoprotein and raise ceritinib exposure, increasing its gastrointestinal, hepatic and QT-related adverse effects. The effect is predicted rather than well characterized.
What this interaction means in plain words
Ceritinib and Dipyridamole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ceritinib belongs to Oncology; Dipyridamole belongs to Cardiovascular.
Why it happens
P-glycoprotein inhibition by dipyridamole may reduce efflux of ceritinib and increase its exposure.
What to do
Monitor for ceritinib toxicity including liver enzymes, ECG and gastrointestinal symptoms, and reduce the dose if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dipyridamole
- Dipyridamole + Riociguat Contraindicated
- Adenosine + Dipyridamole Major
- Betrixaban + Dipyridamole Major
- Dabigatran + Dipyridamole Major
- Dipyridamole + Regadenoson Major
- Dipyridamole + Venetoclax Major
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Dipyridamole?
MediHelp rates the interaction as moderate. Ceritinib and Dipyridamole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dipyridamole may inhibit P-glycoprotein and raise ceritinib exposure, increasing its gastrointestinal, hepatic and QT-related adverse effects. The effect is predicted rather than well characterized.
How serious is the interaction between Ceritinib and Dipyridamole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for ceritinib toxicity including liver enzymes, ECG and gastrointestinal symptoms, and reduce the dose if adverse effects emerge.
What other medicines interact with Dipyridamole?
MediHelp also lists interactions of Dipyridamole with, for example, Riociguat, Adenosine, Betrixaban. The full list is on the Dipyridamole page.
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