Drug interactions
Ceritinib + Erlotinib
Severity: Moderate
Ceritinib and Erlotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib inhibits CYP3A4 and may raise erlotinib concentrations, increasing the risk of rash, diarrhea and other dose-related adverse effects of erlotinib. Both agents also have overlapping gastrointestinal and hepatic toxicity.
What this interaction means in plain words
Ceritinib and Erlotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ceritinib belongs to Oncology; Erlotinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated erlotinib metabolism by ceritinib.
What to do
Monitor for erlotinib toxicity such as severe diarrhea, rash and liver enzyme elevation. Reduce the erlotinib dose in steps if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erlotinib
- Amobarbital + Erlotinib Major
- Apalutamide + Erlotinib Major
- Carbamazepine + Erlotinib Major
- Cobicistat + Erlotinib Major
- Darunavir + Erlotinib Major
- Dexlansoprazole + Erlotinib Major
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Erlotinib?
MediHelp rates the interaction as moderate. Ceritinib and Erlotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceritinib inhibits CYP3A4 and may raise erlotinib concentrations, increasing the risk of rash, diarrhea and other dose-related adverse effects of erlotinib. Both agents also have overlapping gastrointestinal and hepatic toxicity.
How serious is the interaction between Ceritinib and Erlotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for erlotinib toxicity such as severe diarrhea, rash and liver enzyme elevation. Reduce the erlotinib dose in steps if adverse effects emerge.
What other medicines interact with Erlotinib?
MediHelp also lists interactions of Erlotinib with, for example, Amobarbital, Apalutamide, Carbamazepine. The full list is on the Erlotinib page.
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