Drug interactions
Ceritinib + Glipizide-metformin
Severity: Moderate
Ceritinib and Glipizide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib commonly causes hyperglycemia, which may reduce the effectiveness of glipizide and metformin. Glucose control may deteriorate during therapy.
What this interaction means in plain words
Ceritinib and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ceritinib belongs to Oncology; Glipizide-metformin belongs to Endocrine.
Why it happens
Ceritinib-associated hyperglycemia, likely via impaired insulin signaling, opposes antidiabetic therapy.
What to do
Monitor blood glucose regularly during ceritinib therapy and intensify antidiabetic treatment as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Glipizide-metformin?
MediHelp rates the interaction as moderate. Ceritinib and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceritinib commonly causes hyperglycemia, which may reduce the effectiveness of glipizide and metformin. Glucose control may deteriorate during therapy.
How serious is the interaction between Ceritinib and Glipizide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose regularly during ceritinib therapy and intensify antidiabetic treatment as needed.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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