Drug interactions
Ceritinib + Levonorgestrel
Severity: Minor
Ceritinib and Levonorgestrel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib inhibits CYP3A4 and may modestly raise levonorgestrel exposure. With an intrauterine system, systemic exposure is low, so the effect is unlikely to matter clinically.
What this interaction means in plain words
Ceritinib and Levonorgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ceritinib belongs to Oncology; Levonorgestrel belongs to Endocrine.
Why it happens
Ceritinib inhibits CYP3A4, reducing levonorgestrel metabolism.
What to do
No dose adjustment is needed; monitor for progestogenic adverse effects if oral levonorgestrel is used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ceritinib and Levonorgestrel, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Levonorgestrel
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Levonorgestrel?
MediHelp rates the interaction as minor. Ceritinib and Levonorgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ceritinib inhibits CYP3A4 and may modestly raise levonorgestrel exposure. With an intrauterine system, systemic exposure is low, so the effect is unlikely to matter clinically.
How serious is the interaction between Ceritinib and Levonorgestrel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor for progestogenic adverse effects if oral levonorgestrel is used.
What other medicines interact with Levonorgestrel?
MediHelp also lists interactions of Levonorgestrel with, for example, Amobarbital, Apalutamide, Belzutifan. The full list is on the Levonorgestrel page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
