Drug interactions
Ceritinib + Metformin-repaglinide
Severity: Moderate
Ceritinib and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib inhibits CYP3A4 and CYP2C8 and may raise repaglinide levels, increasing hypoglycemia risk. Ceritinib also commonly causes hyperglycemia, which may work against the antidiabetic therapy.
What this interaction means in plain words
Ceritinib and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ceritinib belongs to Oncology; Metformin-repaglinide belongs to Endocrine.
Why it happens
CYP3A4/CYP2C8 inhibition reduces repaglinide clearance, while ceritinib-associated hyperglycemia opposes antidiabetic effect.
What to do
Monitor blood glucose frequently and reduce the repaglinide dose if hypoglycemia occurs; adjust therapy if hyperglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Ceritinib and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceritinib inhibits CYP3A4 and CYP2C8 and may raise repaglinide levels, increasing hypoglycemia risk. Ceritinib also commonly causes hyperglycemia, which may work against the antidiabetic therapy.
How serious is the interaction between Ceritinib and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently and reduce the repaglinide dose if hypoglycemia occurs; adjust therapy if hyperglycemia develops.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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