Drug interactions
Ceritinib + Nifedipine
Severity: Moderate
Ceritinib and Nifedipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib inhibits CYP3A4 and may raise nifedipine exposure, leading to hypotension, flushing and peripheral edema. Ceritinib can also cause bradycardia and QT prolongation, which may add to cardiovascular effects.
What this interaction means in plain words
Ceritinib and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ceritinib belongs to Oncology; Nifedipine belongs to Cardiovascular.
Why it happens
Ceritinib inhibits CYP3A4, reducing nifedipine metabolism; nifedipine P-gp effects on ceritinib are minor.
What to do
Monitor blood pressure and heart rate and reduce the nifedipine dose if hypotension or edema develops. Check ECG and electrolytes as indicated for ceritinib.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nifedipine
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Nifedipine?
MediHelp rates the interaction as moderate. Ceritinib and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceritinib inhibits CYP3A4 and may raise nifedipine exposure, leading to hypotension, flushing and peripheral edema. Ceritinib can also cause bradycardia and QT prolongation, which may add to cardiovascular effects.
How serious is the interaction between Ceritinib and Nifedipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and reduce the nifedipine dose if hypotension or edema develops. Check ECG and electrolytes as indicated for ceritinib.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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