Drug interactions
Ceritinib + Pantoprazole
Severity: Moderate
Ceritinib and Pantoprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pantoprazole raises gastric pH, and ceritinib solubility falls as pH rises, so its absorption may be reduced. The effect is more marked when ceritinib is taken fasted, and it could reduce antitumour efficacy.
What this interaction means in plain words
Ceritinib and Pantoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ceritinib belongs to Oncology; Pantoprazole belongs to Gastrointestinal Tract.
Why it happens
Higher gastric pH lowers the solubility and absorption of ceritinib.
What to do
Avoid proton pump inhibitors if possible, or use an H2 blocker or antacid with staggered timing. If a PPI is essential, monitor tumour response and ceritinib tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pantoprazole
- Pantoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Pantoprazole Major
- Atazanavir + Pantoprazole Major
- Dacomitinib + Pantoprazole Major
- Dasatinib + Pantoprazole Major
- Erlotinib + Pantoprazole Major
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Pantoprazole?
MediHelp rates the interaction as moderate. Ceritinib and Pantoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pantoprazole raises gastric pH, and ceritinib solubility falls as pH rises, so its absorption may be reduced. The effect is more marked when ceritinib is taken fasted, and it could reduce antitumour efficacy.
How serious is the interaction between Ceritinib and Pantoprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid proton pump inhibitors if possible, or use an H2 blocker or antacid with staggered timing. If a PPI is essential, monitor tumour response and ceritinib tolerability.
What other medicines interact with Pantoprazole?
MediHelp also lists interactions of Pantoprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Pantoprazole page.
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