Drug interactions
Ceritinib + Tolterodine
Severity: Moderate
Ceritinib and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib is a CYP3A4 inhibitor and can increase tolterodine exposure. Tolterodine is also a QT-prolonging drug, and ceritinib prolongs QT, so the combination adds to arrhythmia risk as well as anticholinergic effects.
What this interaction means in plain words
Ceritinib and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ceritinib belongs to Oncology; Tolterodine belongs to Genitourinary.
Why it happens
CYP3A4 inhibition by ceritinib reduces tolterodine clearance, with additive QT effects.
What to do
Limit tolterodine to 1 mg twice daily (or 2 mg daily for the extended-release form) and monitor ECG and electrolytes, watching for anticholinergic effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolterodine
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Tolterodine?
MediHelp rates the interaction as moderate. Ceritinib and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceritinib is a CYP3A4 inhibitor and can increase tolterodine exposure. Tolterodine is also a QT-prolonging drug, and ceritinib prolongs QT, so the combination adds to arrhythmia risk as well as anticholinergic effects.
How serious is the interaction between Ceritinib and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit tolterodine to 1 mg twice daily (or 2 mg daily for the extended-release form) and monitor ECG and electrolytes, watching for anticholinergic effects.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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