Drug interactions
Ceritinib + Vinorelbine
Severity: Moderate
Ceritinib and Vinorelbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib inhibits CYP3A4 and may raise vinorelbine exposure. This can increase myelosuppression (neutropenia), neurotoxicity and constipation.
What this interaction means in plain words
Ceritinib and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ceritinib belongs to Oncology; Vinorelbine belongs to Oncology.
Why it happens
Ceritinib inhibits CYP3A4, reducing the metabolic clearance of vinorelbine.
What to do
Monitor blood counts and neurologic and gastrointestinal toxicity closely. Reduce the vinorelbine dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinorelbine
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Vinorelbine?
MediHelp rates the interaction as moderate. Ceritinib and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceritinib inhibits CYP3A4 and may raise vinorelbine exposure. This can increase myelosuppression (neutropenia), neurotoxicity and constipation.
How serious is the interaction between Ceritinib and Vinorelbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neurologic and gastrointestinal toxicity closely. Reduce the vinorelbine dose if toxicity develops.
What other medicines interact with Vinorelbine?
MediHelp also lists interactions of Vinorelbine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Belatacept. The full list is on the Vinorelbine page.
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