Drug interactions
Certolizumab pegol + Denosumab
Severity: Moderate
Certolizumab pegol and Denosumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents have been associated with serious infections. Combined use may add to the infection risk, particularly in patients who are already immunocompromised.
What this interaction means in plain words
Certolizumab pegol and Denosumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Certolizumab pegol belongs to Musculoskeletal; Denosumab belongs to Oncology.
Why it happens
Possible additive infection risk from TNF blockade and RANKL inhibition.
What to do
Monitor for infection, especially skin and urinary tract, and treat early. Review the need for continued therapy if a serious infection develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Certolizumab pegol
- Adenovirus types 4 and 7 live + Certolizumab pegol Contraindicated
- Bcg intravesical live + Certolizumab pegol Contraindicated
- Bcg vaccine live + Certolizumab pegol Contraindicated
- Certolizumab pegol + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Certolizumab pegol + Measles mumps and rubella vaccine Contraindicated
- Certolizumab pegol + Measles mumps and rubella vaccine live Contraindicated
Other interactions of Denosumab
- Abatacept + Denosumab Moderate
- Adalimumab + Denosumab Moderate
- Alefacept + Denosumab Moderate
- Alemtuzumab + Denosumab Moderate
- Anakinra + Denosumab Moderate
- Azacitidine + Denosumab Moderate
Frequently asked questions
Can I take Certolizumab pegol with Denosumab?
MediHelp rates the interaction as moderate. Certolizumab pegol and Denosumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents have been associated with serious infections. Combined use may add to the infection risk, particularly in patients who are already immunocompromised.
How serious is the interaction between Certolizumab pegol and Denosumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for infection, especially skin and urinary tract, and treat early. Review the need for continued therapy if a serious infection develops.
What other medicines interact with Certolizumab pegol?
MediHelp also lists interactions of Certolizumab pegol with, for example, Adenovirus types 4 and 7 live, Bcg intravesical live, Bcg vaccine live. The full list is on the Certolizumab pegol page.
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