Drug interactions
Cetirizine + Erdafitinib
Severity: Minor
Cetirizine and Erdafitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erdafitinib can inhibit intestinal P-glycoprotein and may raise exposure to P-gp substrates such as cetirizine. Cetirizine has a wide therapeutic margin, so the effect is generally limited to more sedation.
What this interaction means in plain words
Cetirizine and Erdafitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cetirizine belongs to Respiratory; Erdafitinib belongs to Oncology.
Why it happens
Inhibition of P-glycoprotein efflux increases absorption and reduces clearance of cetirizine.
What to do
No routine adjustment is needed; watch for increased drowsiness. If it occurs, lower the cetirizine dose or separate dosing by about 6 hours.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cetirizine
- Acrivastine + Cetirizine Moderate
- Amisulpride + Cetirizine Moderate
- Asenapine + Cetirizine Moderate
- Avapritinib + Cetirizine Moderate
- Benzhydrocodone / acetaminophen + Cetirizine Moderate
- Brexpiprazole + Cetirizine Moderate
Other interactions of Erdafitinib
Frequently asked questions
Can I take Cetirizine with Erdafitinib?
MediHelp rates the interaction as minor. Cetirizine and Erdafitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Erdafitinib can inhibit intestinal P-glycoprotein and may raise exposure to P-gp substrates such as cetirizine. Cetirizine has a wide therapeutic margin, so the effect is generally limited to more sedation.
How serious is the interaction between Cetirizine and Erdafitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; watch for increased drowsiness. If it occurs, lower the cetirizine dose or separate dosing by about 6 hours.
What other medicines interact with Cetirizine?
MediHelp also lists interactions of Cetirizine with, for example, Acrivastine, Amisulpride, Asenapine. The full list is on the Cetirizine page.
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