Drug interactions
Cetirizine + Sotorasib
Severity: Minor
Cetirizine and Sotorasib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib is a P-glycoprotein inhibitor and may increase cetirizine levels, not decrease them. Cetirizine has a wide therapeutic margin, so clinically important effects are unlikely beyond more drowsiness.
What this interaction means in plain words
Cetirizine and Sotorasib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cetirizine belongs to Respiratory; Sotorasib belongs to Oncology.
Why it happens
Sotorasib inhibits P-gp efflux, which can modestly increase cetirizine exposure.
What to do
No routine adjustment is needed. Monitor for increased sedation and reduce the cetirizine dose if it occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cetirizine
- Acrivastine + Cetirizine Moderate
- Amisulpride + Cetirizine Moderate
- Asenapine + Cetirizine Moderate
- Avapritinib + Cetirizine Moderate
- Benzhydrocodone / acetaminophen + Cetirizine Moderate
- Brexpiprazole + Cetirizine Moderate
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Cetirizine with Sotorasib?
MediHelp rates the interaction as minor. Cetirizine and Sotorasib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sotorasib is a P-glycoprotein inhibitor and may increase cetirizine levels, not decrease them. Cetirizine has a wide therapeutic margin, so clinically important effects are unlikely beyond more drowsiness.
How serious is the interaction between Cetirizine and Sotorasib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for increased sedation and reduce the cetirizine dose if it occurs.
What other medicines interact with Cetirizine?
MediHelp also lists interactions of Cetirizine with, for example, Acrivastine, Amisulpride, Asenapine. The full list is on the Cetirizine page.
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