Drug interactions
Cetirizine + Zuranolone
Severity: Moderate
Cetirizine and Zuranolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zuranolone produces somnolence and impaired psychomotor performance, and cetirizine can add to drowsiness. The combination may increase impairment of driving and daily activities.
What this interaction means in plain words
Cetirizine and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cetirizine belongs to Respiratory; Zuranolone belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A modulation and H1 antagonism.
What to do
Consider reducing the zuranolone dose if sedation occurs, or switch to a less sedating antihistamine like loratadine. Advise against driving while impaired.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cetirizine
- Acrivastine + Cetirizine Moderate
- Amisulpride + Cetirizine Moderate
- Asenapine + Cetirizine Moderate
- Avapritinib + Cetirizine Moderate
- Benzhydrocodone / acetaminophen + Cetirizine Moderate
- Brexpiprazole + Cetirizine Moderate
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Cetirizine with Zuranolone?
MediHelp rates the interaction as moderate. Cetirizine and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zuranolone produces somnolence and impaired psychomotor performance, and cetirizine can add to drowsiness. The combination may increase impairment of driving and daily activities.
How serious is the interaction between Cetirizine and Zuranolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the zuranolone dose if sedation occurs, or switch to a less sedating antihistamine like loratadine. Advise against driving while impaired.
What other medicines interact with Cetirizine?
MediHelp also lists interactions of Cetirizine with, for example, Acrivastine, Amisulpride, Asenapine. The full list is on the Cetirizine page.
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